surgical oncology | CANCER Immunology
CROMPTON
LABORATORY
LEVERAGING THE THERAPEUTIC POTENTIAL OF B- AND T-CELLS
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Our Research
The UCLA Crompton Lab engages in laboratory and clinical investigations to elucidate mechanisms of immunological memory with the aim of developing novel immunotherapies for cancer patients. In particular, we study:
- the induction and composition of intra-tumoral tertiary lymphoid structures, with a current focus on the role of B cells in antigen presentation and generation of a neoantigen specific humoral response.
- the ontogeny of activated CD8 T cells with the aim of elucidating key epigenetic, signal transduction, and metabolic features critical for the development of long-lived memory T cells; previously finding that inhibition of the serine/threonine kinase Akt results in the formation of long-lived T cells with potent anti-tumor activity.
Lab Members
If you want to build a ship, don’t drum up people together to collect wood and don’t assign them tasks and work, but rather teach them to long for the endless immensity of the sea.
ANTOINE DE SAINT-EXUPÉRY
Principal Investigator
SRAII, Lab Manager
SRAI
Surgical Oncology Resident
Surgical Oncology Resident
Postdoctoral Scholar
Surgical Oncology Resident
Surgical Oncology Resident
Undergraduate Student
Undergraduate Student
High School Student
Orthopaedic Oncology Fellow
Undergraduate Student
Undergraduate Student
Select Publications
Cancer Immunology
Clonal redemption of b cells in cancer
Tyler R McCaw, Serena Y Lofftus, Joseph G Crompton, Frontiers in Immunology, 2023 october
Cancer-Associated B Cells in Sarcoma
Joseph K. Kendal, Michael S. Shehata, Serena Y. Lofftus, Joseph G. Crompton
Cancers, vol. 15, 2023
Lesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade
Osorio JC, Arbour KC, Le DT, Durham JN, Plodkowski AJ, Halpenny DF, Ginsberg MS, Sawan P, Crompton JG, Yu HA, Namakydoust A, Nabet BY, Chaft JE, Riely GJ, Rizvi H, Diaz LA Jr, Hellmann
MD. J Clin Oncol. 2019 Dec 20
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
C. Klebanoff, Joseph G. Crompton, A. Leonardi, Tori N. Yamamoto, Smita S Chandran, R. Eil, Madhusudhanan Sukumar, S. Vodnala, Jinhui Hu, Y. Ji, D. Clever, Mary A. Black, Devikala Gurusamy, M. Kruhlak, P. Jin, D. Stroncek, L. Gattinoni, S. Feldman, N. Restifo
JCI insight, 2017 Dec 7
Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape
Crompton JG, Narayanan M, Cuddapah S, Roychoudhuri R, Ji Y, Yang W, Patel SJ, Sukumar M, Palmer DC, Peng W, Wang E, Marincola FM, Klebanoff CA, Zhao K, Tsang JS, Gattinoni L, Restifo NP.
Cell Mol Immunol. 2016 July
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics
Crompton JG, Sukumar M, Roychoudhuri R, Clever D, Gros A, Eil RL, Tran E, Hanada K, Yu Z, Palmer
DC, Kerkar SP, Michalek RD, Upham T, Leonardi A, Acquavella N, Wang E, Marincola FM, Gattinoni L,
Muranski P, Sundrud MS, Klebanoff CA, Rosenberg SA, Fearon DT, Restifo NP.
Cancer Res. 2015 Jan 15
Surgical Oncology
Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma
Patel SP, Othus M, Chen Y, Wright GP Jr, Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Truong TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Grossmann KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sondak VK, Ribas A.
N Engl J Med. 2023 Mar 2;388(9):813-823. doi: 10.1056/NEJMoa2211437. PMID: 36856617 Clinical Trial.
Lifelong Imaging Surveillance is Indicated for Patients with Primary Retroperitoneal Liposarcoma
Eckardt MA, Graham DS, Klingbeil KD, Lofftus SY, McCaw TR, Bailey MJ, Goldring CJ, Kendal JK, Kadera BE, Nelson SD, Dry SM, Kalbasi AK, Singh AS, Chmielowski B, Eilber FR, Eilber FC, Crompton JG.
Ann Surg Oncol. 2023 May;30(5):3097-3103. doi: 10.1245/s10434-022-12977-0. Epub 2022 Dec 29. PMID: 36581724
18F-FLT PET/CT as a Prognostic Imaging Biomarker of Disease-Specific Survival in Patients with Primary Soft-Tissue Sarcoma
J. Crompton, W. Armstrong, M. Eckardt, Ameen Seyedroudbari, W. Tap, S. Dry, Evan R. Abt, J. Calais, K. Herrmann, J. Czernin, F. Eilber, M. Benz
The Journal of Nuclear Medicine, 2021
Local Control of Soft Tissue and Bone Sarcomas
Crompton JG, Ogura K, Bernthal NM, Kawai A, Eilber FC.
J Clin Oncol. 2018 Jan 10;36(2):111-117. doi: 10.1200/JCO.2017.75.2717. Epub 2017 Dec 8. PMID: 29220297
Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
Crompton JG, Klemen N, Kammula US.
Ann Surg Oncol. 2018 Feb;25(2):565-572. doi: 10.1245/s10434-017-6266-8. Epub 2017 Nov 29.
Full List of Publications Available here
Funding
Our research is supported By:
- The National Institutes of Health
- The National Cancer Institute
- UCLA Jonsson Comprehensive Cancer Center
- UCLA Broad Stem Cell Research Center
- UCLA Sarcoma Program
- UCLA Clinical and Translational Science Institute
- The David Geffen School of Medicine
- The American Surgical Association Foundation Fellowship Research Award
- The American College of Surgeons
- The Ruby Family Foundation
- Christy and Paul Mosesian
- Tower Cancer Research Foundation
If you are interested in supporting our work, please contact the Jonsson Comprehensive Cancer Foundation:
JCCF@MEDNET.UCLA.EDU
Contact Us
University of California Los Angeles
650 Charles E. Young Drive
Center for Health Sciences, 64-200
Los Angeles, CA 90095
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